Cody Zeller scored 18 points and Victor Oladipo added 13, giving No. 18 Indiana a 70-55 victory over No. 5 Michigan State on Tuesday night.
The Hoosiers (23-7, 10-7 Big Ten) became the second team in less than a week to beat three top five teams this season.
Kansas also achieved a feat only one other Indiana team had done since 1948-49.
Draymond Green had 29 points for Michigan State (24-6, 13-4), which had won seven straight and was trying to clinch its second outright league title in four seasons.
The Hoosiers used a 12-2 run to build an 18-8 lead.
Michigan State never got closer than four points the rest of the way.
It was Indiana coach Tom Crean's first victory against his former boss, Tom Izzo.
Copyright 2012 by The Associated Press. All Rights Reserved.