Omar Infante's RBI single in the 8th inning broke a scoreless tie, leading the Tigers past the White Sox 1-0.
Anibal Sanchez (14-7) started and earned the win, going 7 and 1/3 innings, allowing 5 hits, and striking out 10. Sanchez's ERA on the season is now 2.50.
Joaquin Benoit pitched a perfect 9th inning to earn his 18th save.
The Tigers have Thursday off and begin a 3-game series vs. the Kansas City Royals on Friday.
Detroit's lead in the AL Central division is now 6.5 games over Cleveland.
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